Is Blueprint by Bryan Johnson HSA/FSA Eligible? Yes, Here’s How!
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Is Blueprint by Bryan Johnson HSA/FSA Eligible? Yes, Here’s How!

· 6 min read HSA/FSA Eligibility

Quick Answer:

Yes, Blueprint by Bryan Johnson is HSA/FSA eligible. You just need a Letter of Medical Necessity (LMN) from a licensed healthcare provider. Under IRS Publication 502, supplements and nutritional products qualify when used to prevent, manage, or reverse conditions like nutrient deficiencies, oxidative stress, or age-related health decline.

Crates Health makes this easy. Get your personalized, compliant LMN and handle your reimbursement in one click.

Key Takeaways

  • Blueprint by Bryan Johnson HSA/FSA Eligible? Yes, Here’s How! is HSA/FSA eligible when used to treat or prevent a diagnosed medical condition
  • You need a Letter of Medical Necessity (LMN) from a healthcare provider to use pre-tax health funds for Blueprint by Bryan Johnson HSA/FSA Eligible? Yes, Here’s How!
  • Common qualifying conditions include arthritis, cardiovascular health, sleep disorders
  • Crates Health streamlines the entire process — get approved in minutes and save 30%+ with pre-tax dollars
  • Per IRS Publication 502, expenses for treatment or prevention of a specific condition qualify as medical expenses

What is Blueprint by Bryan Johnson

Blueprint is the comprehensive longevity supplement system created by tech entrepreneur Bryan Johnson, who famously spends over $2 million annually on his personal anti-aging protocol and has been featured in Bloomberg, WIRED, and countless health publications for his obsessive approach to reversing biological aging. The system delivers clinically-researched compounds in precise, science-backed dosages designed to target the biological mechanisms of aging.

The core product line includes the Longevity Mix (13 active ingredients replacing 20+ individual supplements), Essential Capsules (24 multi-nutrients), and high-quality extra virgin olive oil – all formulated based on extensive biomarker testing and analysis of thousands of research papers. Each product contains specific compounds like NAD+ precursors, resveratrol, spermidine, curcumin, and CoQ10 at therapeutic doses shown to support cellular health and longevity.

What sets Blueprint apart from typical supplements is its foundation in measurable outcomes. Research published in Cell Metabolism has demonstrated that NAD+ precursors like those in Blueprint can restore cellular energy production that declines with age. A meta-analysis in the Journal of Clinical Medicine found that resveratrol supplementation improves cardiovascular markers and insulin sensitivity. Rather than generic “anti-aging” claims, Blueprint focuses on specific biological pathways – mitochondrial function, autophagy, inflammation – supported by peer-reviewed research, making advanced longevity science accessible through convenient, precisely-dosed products.

Why Blueprint Qualifies for HSA/FSA

According to IRS regulations, longevity supplements can qualify as eligible medical expenses with a Letter of Medical Necessity under specific circumstances outlined in Publication 502.

IRS Publication 502 states that medical expenses are “the costs of diagnosis, cure, mitigation, treatment, or prevention of disease, and for the purpose of affecting any part or function of the body,” but “must be primarily to alleviate or prevent a physical or mental condition or illness.”

This means Blueprint supplements can qualify for HSA/FSA reimbursement for prevention or treatment of:

  • Age-related cognitive decline and neurodegeneration – Research in Frontiers in Aging Neuroscience demonstrates that NAD+ precursors support neuronal health and cognitive function. A systematic review in Nutrients found that compounds like resveratrol and curcumin show neuroprotective effects against age-related cognitive decline.
  • Cardiovascular disease prevention – The American Heart Association recognizes that omega-3 fatty acids and extra virgin olive oil support cardiovascular health. A meta-analysis in the Journal of the American College of Cardiology found that CoQ10 supplementation improves endothelial function and reduces cardiovascular risk markers.
  • Metabolic disorders and mitochondrial dysfunction – According to research in Cell Metabolism, NAD+ decline is a hallmark of metabolic dysfunction and aging. Supplementation with NAD+ precursors has been shown to restore metabolic function in multiple clinical trials.
  • Oxidative stress and cellular damage – A Cochrane review found that antioxidant supplementation can reduce markers of oxidative stress. Blueprint’s combination of resveratrol, vitamin E, and other antioxidants targets free radical damage linked to chronic disease.
  • Chronic inflammation – Research published in the Journal of Clinical Investigation demonstrates that curcumin has potent anti-inflammatory effects comparable to some pharmaceuticals. The Arthritis Foundation recognizes curcumin’s role in managing inflammation-related conditions.
  • Nutrient deficiencies affecting health – The CDC reports that nutrient deficiencies are widespread, with significant portions of the population deficient in vitamin D, magnesium, and B vitamins. Blueprint’s Essential Capsules address these common deficiencies at therapeutic doses.
  • Sarcopenia and muscle health disorders – Research in the Journal of Cachexia, Sarcopenia and Muscle shows that specific nutrients including vitamin D, omega-3s, and protein support muscle preservation and function with aging.
  • Sleep disorders and circadian dysfunction – Studies in Sleep Medicine Reviews indicate that magnesium and other compounds in Blueprint support healthy sleep architecture and circadian rhythm regulation.

The key requirement is that your healthcare provider must note the longevity supplementation as medically necessary for preventing, managing, or reversing your specific health condition, not just for general anti-aging. This documentation comes in the form of a Letter of Medical Necessity (LMN).

How to Assess Your HSA/FSA Eligibility for Blueprint by Bryan Johnson

Traditional Route: Schedule an appointment with your primary care physician, discuss your health optimization goals and supplement needs, and request a Letter of Medical Necessity if longevity supplementation is recommended as part of your treatment plan. This typically requires an office visit, potential wait times, and can cost $50-100+ depending on your insurance.

Faster, Smarter Route: Use Crates Health to get your Letter of Medical Necessity online in just a few minutes. Our platform connects you with licensed healthcare providers who can evaluate your conditions remotely and issue the appropriate documentation if you qualify. No office visits, no waiting weeks for appointments, and no surprise medical bills.

Check your Eligibility

Frequently Asked Questions

Do other longevity and anti-aging supplements qualify for HSA/FSA?

Absolutely! With the right medical documentation, you can potentially use HSA/FSA funds for other supplement brands like Thorne , AG1 , Momentous , and Ritual , as long as they're recommended for treating specific medical conditions. Check out our complete vitamins and supplements guide for more options. Related guides: Thorne (https://www.crateshealth.com/blog/hsa-fsa-eligibility/thorne/), AG1 (https://www.crateshealth.com/blog/hsa-fsa-eligibility/ag1/), Momentous (https://www.crateshealth.com/blog/hsa-fsa-eligibility/momentous/), Ritual (https://www.crateshealth.com/blog/hsa-fsa-eligibility/ritual-vitamins/)

How does reimbursement work?

Some retailers accept HSA/FSA cards (most don't though). When they don't, you need to use your personal card and then reimburse yourself. This means finding and storing receipts and then uploading them and your LMN to your HSA/FSA admin portal. With Crates Health , we make this process simple: upload your receipt and get one-click reimbursements all from our platform.

What is a Letter of Medical Necessity?

A Letter of Medical Necessity (LMN) is a document from a licensed healthcare provider that explains why a specific expense like your Blueprint supplements is medically necessary for treating a diagnosed condition. It's the official paperwork that proves your longevity supplementation isn't just for general anti-aging. Each LMN typically remains valid for 12 months from the date of issue.

Will my claim get denied?

With proper documentation, denials are rare. That said, every HSA/FSA administrator is different, and some may initially deny claims due to receipt format, LMN documentation, or unclear medical necessity. Crates Health supports you through any denials and makes sure you get reimbursed.

Can I use my HSA/FSA for Blueprint if I've already been buying it?

Yes, but only for purchases made ON OR AFTER your LMN is issued. You cannot retroactively reimburse past Blueprint purchases with a newly obtained LMN. The LMN must be in place before the purchase is made. Get your LMN today and your future Blueprint orders become HSA/FSA eligible immediately.

Do I need a separate LMN for each Blueprint product?

Generally, one LMN can cover your Blueprint supplement protocol if it's documented for the same health condition. However, best-in-class LMNs are designed for one product and one specific health condition to meet IRS standards. Crates Health makes getting multiple LMNs simple and fast.

Anchor Ebanks

Written by

Anchor Ebanks

Anchor Ebanks is an HSA/FSA optimization expert featured in Yahoo Finance, The American Journal of Healthcare Strategy, Admissions Gateway, and Poets & Quants. He attended Harvard Business School and was an AI research fellow at the Berkman Klein Center for Internet & Society focused on healthcare access. Prior to wellness benefits, he spent nearly a decade at Google, YouTube, and Deloitte. Connect on LinkedIn, Twitter, or at anchor@crateshealth.com.